If you can tweak the thrusters, to should be able to balance the thrust out, it would just be a lot of tweaking to get it to work. Once you’ve got it to work, you will of course also have to worry about taking damage, although that would throw symmetrical ships off balance too. You could also possible use small maneuvering thrusters for rotations to balance out the forces, which might make dealing with balance changes due to damage easier, maybe with a script that auto-stabilizes you. You would then of course have to worry about not going straight forward. Assymetrical ships will almost certainly be harder to make and design, but seems like a fun little challenge, and if you get good at it, I imagine it would be a good distinguishing feature in the design market.