Probably not a new brazen idea... but right now we could use more reasons to strap in with friends for PVP and high risk missions. The economy engine needs it and the player experience would feel much fuller for it.
These are merely ideas to help you ponder your own vision of this suggestion. Please don't take all elements to heart, but do voice your alterations if any.
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Anomaly fields.
Uninhabitable. Hazardous. Exclusively lucrative.
Uninhabitable:
Potentially includes anomaly terminal or rotating event phases of complete annihilation of dwellers and constructs.
Allows for field respawning and repositioning of hazards and high-value resources
Discourages encampments
Promotes exploration and chance encounters
Hazardous:
Navigational hazards
Canyons, caverns, debris fields
Dense gas/ice fields
Dynamic Environmental hazards
Intense meteorite showers (with radar warnings/alarms)
Heat (voxel/element resistance/decay?)
Catalytic storms - radiation, heat, electro, etc either naturally occurring or artificially caused by depletion or interaction (such as bumping into a dense gas field boundary)
Lucrative:
New environmental requirements for processing/production of special commodities
Product instability requiring frequent egress of materials to given distance.
Ship wreck salvage missions
'Control zones' of exclusive valuable resources.
Stimulates the economy in countless ways continuously
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This is intentionally an incomplete list of ideas to summarize. Suggest what you would add or change in the comments! I'll ultimately add ideas that help give the idea further imagination in future edits.