In Space Engineers I often find myself accidentily removing blocks from ships and stations (on creative mode at least), as all it takes is a single click and the targetting system isn't great.
What would be a good idea is if you could 'lock' the ability to modify something. Say for example you've built a ship and you're happy with it, you can enable the lock to prevent it being changed, though you should of course be able to unlock it too.